Tesamorelin GHRH Analog Research Hub
Tesamorelin research — FDA-approved GHRH analog studied for growth hormone secretion, visceral adipose tissue reduction, HIV lipodystrophy, cognitive function, and metabolic optimization.
Featured Research
In-depth research profiles with mechanisms of action, key findings, and peer-reviewed citations.
Tesamorelin Acetate
Also known as: Tesamorelin, Egrifta, TH9507
Tesamorelin is a synthetic analogue of human GHRH (growth hormone-releasing hormone) comprising all 44 amino acids of native GHRH with an added trans-3-hexenoic acid moiety at the N-terminus. This modification enhances resistance to DPP-4 enzymatic degradation without altering receptor binding affinity, resulting in improved bioavailability compared to native GHRH. Tesamorelin is FDA-approved unde...
Quick Facts
Sequence: Trans-3-hexenoic acid-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Ty...
MW: 5135.90 g/mol
CAS: 804475-66-9
Store lyophilized powder at -20C. Reconstituted solution should be refrigerated at 2-8C and used within 14 days. Protect...
Latest Research Articles
Deep-dive articles from the System Peptides Research Network.
What Is Tesamorelin? GHRH Analog Research Review
Research review of Tesamorelin — the synthetic GHRH analog studied for growth hormone secretion and visceral adipose tis...
Read Article Research ScienceGrowth Hormone Releasing Pathways: GHRH vs GHS-R Mechanisms
Two pathways, one outcome: how GHRH receptor and ghrelin receptor (GHS-R) signaling converge on growth hormone release, ...
Read Article Category RoundupGrowth Hormone Secretagogues: A Complete Research Guide
Everything researchers need to know about GH secretagogues — Ipamorelin, CJC-1295, GHRP-6, Tesamorelin, and how they dif...
Read ArticleResearch Applications
Key research categories and applications studied in the scientific literature.
Weight Loss & Fat Metabolism
A GHRH analog frequently used to target visceral fat — the dangerous abdominal fat linked to metabolic syndrome, cardiovascular risk, and insulin resistance.
Lean Mass & Body Composition
Highly effective at reducing visceral fat while simultaneously preserving lean muscle mass, making it excellent for body recomposition research.
Insulin Sensitivity
A growth hormone-releasing hormone analog that is highly effective at reducing abdominal visceral fat, which directly improves insulin sensitivity.
Anti-Aging & Longevity
Boosts natural growth hormone production through the GHRH receptor, aiding in better sleep, fat loss, and muscle repair — key markers of healthy aging.
Frequently Asked Questions
Common questions about tesamorelin research research, purity standards, and sourcing.
What is Tesamorelin?
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) with a trans-3-hexenoic acid modification that increases stability. It is the only GHRH analog with FDA approval (as Egrifta) for reducing visceral adipose tissue in HIV-associated lipodystrophy.
How does Tesamorelin stimulate growth hormone?
Tesamorelin binds the GHRH receptor on anterior pituitary somatotroph cells, stimulating pulsatile GH release that preserves the natural diurnal secretion pattern. Unlike exogenous GH, it maintains feedback regulation and does not suppress endogenous GH production.
What has Tesamorelin been studied for beyond HIV lipodystrophy?
Research has explored Tesamorelin for cognitive function in aging (GHRH-GH-IGF-1 axis and neuroplasticity), general visceral adiposity reduction, metabolic syndrome markers, and as a tool for studying pulsatile GH secretion physiology.
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